Structural biology

Structural biology

doesn't know which Academy member is handling the paper unless it is accepted. To make room for the extra papers to be submitted via track II, PNAS has reduced the number of papers a member is allowed to communicate to the journal annually from six to four. Does the new system work? Those who have tried it say that there are many frustrating teething problems. Apparently one problem is that the...

Structural biology and cancer

The techniques of structural biology currently play an important role in the development of novel therapeutic agents including cancer chemotherapies. X-ray crystallography has proved to be a particularly powerful tool for both the discovery of novel compounds and their subsequent development. In this review of the literature, the steps involved in the determination of a crystal structure will b...

Structural Biology of Glycoproteins

Structural Biology Software Systems

Advances in our understanding of macromolecular structure come from experimental methods, such as X-ray crystallography, and also computational analysis of the growing number of atomic models obtained from such experiments. The later analyses have made it possible to develop powerful tools for structure prediction and optimization in the absence of experimental data. In recent years, a synergy ...

Structural Biology Using OpenDX

CRABP I and CRABP II are two very similar proteins that transport retinoic acid in the body. Both proteins take virtually the same shape but differ by 30 out of 138 amino acids and are found in different locations within living tissues. The proteins also show dramatic differences in binding to a partner protein. Which of the 30 amino acids are responsible? There are too many combinations for si...